Supervivencia en las personas que viven con VIH en el marco del sistema de salud colombiano 2011-2018 / Survival in people living with HIV in the framework the Colombian health system: 2011-2018

Resumen Objetivo: Describir la supervivencia a siete años y los principales factores asociados a esta, en las personas con VIH que fueron atendidas en el sistema de salud colombiano entre 2011 a 2018. Métodos: Análisis de supervivencia de una cohorte de 64 039 personas diagnosticadas con VIH en Colombia. Se aplicó el método de Kaplan-Meier para estimar la probabilidad de supervivencia a partir de la fecha del diagnóstico. Se ajustó un modelo de supervivencia paramétrico flexible de Royston Parmar. Resultados: La estimación de la supervivencia global a 7 años fue de 94,8% (IC 95%: 94,5-95,2). El mayor riesgo de muerte se presentó en los hombres (HR: 1,2; IC 95%: 1,1-1,4; p: 0,010); en personas ≥50 años de edad (HR: 3,1; IC 95%: 1,6-6,3; p: 0,002); en el régimen subsidiado (HR: 2,2; IC 95%: 1,9-2,5; p: <0,001); en la etapa sida (HR: 2,8; IC 95%: 2,1-3,7; p: <0,001); en quienes presentaron la última carga viral detectable (HR: 7,1; IC 95%: 6,0-8,3; p: <0,001); y en quienes mostraron conteo de linfocitos T CD4+ <350 células/μL (HR: 1,9; IC 95%: 1,4-2,4; p: <0,001). Conclusión: La probabilidad de la supervivencia de las personas que viven con VIH aumenta al ser diagnosticados en edades jóvenes, en quienes presenten un recuento de linfocitos T CD4+ ≥350 células/μL, una carga viral indetectable (< 50 copias/mL) y no se encuentren en etapa sida.

Summary Objective: to describe the seven-year survival and predictors of mortality among people with HIV who were treated in the Colombian health system between 2011 and 2018. Methods: 64 039 people diagnosed with HIV in Colombia were included. Kaplan-Meier analysis estimated the probability of survival from the date of diagnosis. A Royston Parmar flexible parametric survival model was fitted. Results: The overall survival at 7 years was 94.8% (95% CI: 94.5-95.2). Survival was related to sex (men, HR: 1.2; 95% CI: 1.1-1.4; p: 0.010); people ≥50 years of age (HR: 3.1; 95% CI: 1.6-6.3; p: 0.002); subsidized regime (HR: 2.2; 95% CI: 1.9-2.5; p: <0.001); AIDS stage (HR: 2.8; 95% CI: 2.1-3.7; p: <0.001); a detectable viral load (HR: 7.1; 95% CI: 6.0-8.3; p: <0.001); and a CD4+ Lymphocyte count <350 cells/μL (HR: 1.9; 95% CI: 1.4-2.4; p: <0.001). Conclusion: The probability of survival of people living with HIV increases when they are diagnosed at a young age, in those with a CD4+ T Lymphocyte count ≥350 cells/μL, an undetectable viral load (<50 copies/mL) and are not in the AIDS stage.

Rheumatoid arthritis in Colombia: a clinical profile and prevalence from a national registry.

BACKGROUND: There is a need to describe the demographic and clinical characteristics of people diagnosed with rheumatoid arthritis who are attended within the Colombian health system. This characterization allows prioritizing populations with specific risks, programming the use of health services, and planning the costs necessary to guarantee equitable care. OBJECTIVE: To assess the demographic and clinical characteristics of a cohort of patients with rheumatoid arthritis using national data collected by the High-Cost Disease Fund (CAC in Spanish). METHODS: A cross-sectional study from a secondary source. Data was gathered from a national administrative registry. A descriptive analysis was performed on sociodemographic and clinical characteristics. Age-standardized prevalence was estimated at national level and by geographical regions. Remission rates were also estimated for Colombian departments and regions. RESULTS: By 2019, 81,386 patients with rheumatoid arthritis were reported in Colombia. The relation female-male was 5.2:1. The median age was 59 years (IQR: 50-67). Prevalence was higher in people aged 50-69 years. The most frequent comorbidities were high blood pressure (31.15%) and osteoporosis (19.46%). Age-standardized prevalence of rheumatoid arthritis was 0.24 per 100 population (95% CI: 0.23-0.24). In cases with complete information, 57.57% of departments had remission rates up to 30%. CONCLUSION: Rheumatoid arthritis in Colombia was more frequent in females aged ≥50 year. Age-standardized prevalence was lower than reported by other studies performed in Colombia but similar to the estimated internationally for the country. Key Points • More than 80,000 rheumatoid arthritis patients were reported to this national registry in Colombia in 2019, finding an age-standardized prevalence of 0.24 per 100 population. • Hypertension was the most common comorbidity reported in people with rheumatoid arthritis. This finding is similar to the reports by similar studies such as the COMORA. • A major strength of this study is the large sample size since data come from a nationwide registry of people with rheumatoid arthritis, supported by the National Ministry of Health. Additionally, this registry has a rigorous data monitoring process that guarantees the internal validity of data and provides valuable information for decision-making based on local evidence. • Prevalence of rheumatoid arthritis was higher in females between 50 and 65 years. Age-standardized prevalence was lower than previously reported in Colombia, but similar to the world estimations.

Healthcare-related expenditures among immigrants and non-immigrants living with HIV in colombia.

The perception that immigrants represent a burden to national health systems can hinder the development of policies for their inclusion in health coverage. In order to inform the development of such policies, data on the healthcare needs and healthcare spending for immigrants is required. The objective of this article is to compare the clinical characteristics and healthcare-related expenditures of Venezuelan immigrants and non-migrants living with HIV in Colombia. We analysed data from the Colombian High-cost Diseases Fund from February 1, 2018 to January 31, 2019, identifying the hospital and non-hospital expenditures per patient for Venezuelan immigrants and non-migrant patients, in both the state-subsidised and the contributory coverage schemes. We employed binomial negative regression models to compare expenditures between the two groups. In the contributory scheme, the average annual per-capita expenditure for immigrants was USD $ 859.07 (SD: ± $793.37) for non-hospital care. For non-migrants, the average costs were 1,796.53. In the state-subsidised scheme expenditures were higher on average, but still lower for immigrants than for non-migrants. After adjusting by clinical and sociodemographic characteristics, non-hospital per capita expenditures were lower for immigrants as compared with non-migrants (25,37% lower in the state-subsidised scheme, and 33,75% lower in the contributory scheme). Hospital expenditures were also lower, but the small sample size limited analysis. To conclude, Venezuelan immigrants living with HIV do not represent a major economic burden to the health system in Colombia. Further studies are required in order to understand if the lower healthcare expenditures of this population are the result of limitations in healthcare access, of clinical characteristics that were not assessed in this study, or of other unmeasured aspects.

Algunos factores de riesgo asociados a la mortalidad infantil en la ciudad de Bogotá, 2008 / Some risk factors associated with infant mortality in Bogota in 2008

Introducción: La tasa de mortalidad infantil en el Distrito Capital para el 2006 fue de 13,5 casos por 1.000 nacidos vivos. Aunque ha venido disminuyendo levemente en los últimos cinco años, la tendencia es a mantenerse estable. Para Bogotá era necesario caracterizar los factores asociados a la mortalidad infantil, que facilitaría las intervenciones de prevención y atención en la niñez menor de un año. Objetivo: Identificar algunos factores asociados a la mortalidad infantil en la ciudad de Bogotá en el 2008, mediante las variables incluidas en los certificados de defunción y los certificados de nacidos vivos. Método: Estudio de casos y controles. 1) Casos: defunciones en menores de un año durante el 2008 en Bogotá, y 2) controles: los nacidos vivos en el 2007 en Bogotá. Se utilizó un análisis bivariado estratificando por bajo peso y edad gestacional. Se empleó un modelo de regresión logística que incluía las variables con un valor de p < 0,10 en el análisis bivariado. Resultados: Los factores de riesgo para mortalidad infantil fueron: la edad gestacional menor de 37 semanas, el peso al nacer menor de 2.500 g, el niveleducativo de la madre con primaria o sin educación, la afiliación al régimen subsidiado y el sexo masculino. Conclusiones: Se identificaron factores de riesgo propios del recién nacido y del control prenatal, así como de la vinculación al Sistema de Seguridad en Salud. Estos factores son potencialmente modificables. Palabras clave: factor de riesgo, mortalidad infantil, peso bajo al nacer, baja edad gestacional, estudio caso-control.

Introduction: Infant mortality in the Bogota for 2006 was 13.5 cases per 1,000 live births. While it has been declining slightly over the past five years the trend has been stable. For Bogota it’s necessary to characterize the factors associated with infant mortality which facilitate the prevention and care interventions in this type of population. Objective: To identify some factors ssociated with infant mortality in Bogotá in 2008 through the variables included in 1death certificates and certificates of live births. Materials and methods: Case-Control Studies: (1) Case: eaths under one year old in 2008 in the Capital District, and (2) control: live births in 2007 in the Capital District. It was used a bivariate analysis, stratified by weight and gestational age. It was used a logistic regression model including the variables with p < 0.10 in the bivariate analysis. Results: The risk factors for infant mortality were: gestational age less than 37 weeks, birth weight less than 2,500 g, mother’s educational level with primary or no education, affiliation to the subsidized regime and males. Conclusions: There are risk factors that can be modified hrough the maternal health care which will prevent preterm births and children with low birth weight. It can reduce the risk of infant mortality, ensuring a good education of the population, improving the quality of care in health services and giving greater attention to males, which is not only risk factor for infant mortality but for some morbidities. Key words: Risk factors, infant mortality, low birth weight, low gestational age, case-control study.